Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida
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چکیده
منابع مشابه
Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida.
Periconceptional folate supplementation reduces the risk of neural-tube defects. We studied the frequency of the 677C-->T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene in 55 patients with spina bifida and parents of such patients (70 mothers, 60 fathers). 5% of 207 controls were homozygous for the 677C-->T mutation compared with 16% of mothers, 10% of fathers, and 13% of...
متن کاملPolymorphisms of the 5,10-methylenetetrahydrofolate and the methionine synthase reductase genes as independent risk factors for spina bifida.
We analyzed the role of the C677T polymorphism of the 5,10-methylenetetrahydrofolate and the A66G polymorphism of the methionine synthase reductase genes as risk factors for occurrence of spina bifida. The studied population included 106 mothers and 104 children from affected families, and a control group of 100 adults. We found statistically significant differences between the occurrence of th...
متن کاملGenetic polymorphism of methylenetetrahydrofolate reductase as a potential risk factor for congenital heart disease
BACKGROUND A meta-analysis of polymorphism C677T (rs1801133) of the methylene tetrahydrofolate reductase (MTHFR) gene as a potential risk factor for congenital heart disease (CHD) in Chinese paediatric population was studied in view of the previously reported controversial results. METHODS We searched literature including PubMed, Embase, Cochrane Library, CNKI, Wanfang, and VIP databases that...
متن کامل[Frequency of C677T polymorphism of 5, 10-methylenetetrahydrofolate reductase (MTHFR) in Chilean mothers of spina bifida cases and controls ].
BACKGROUND Several population studies have shown that patients with neural tube defects (NTD), have a higher frequency of a genetic mutation related with thermolability of the enzyme 5,10-metylentetrahydrofolate reductase (MTHFR). There are regional and ethnic variations in the genotypic or allelic frequency of this mutation and its possible relationship with NTD and others congenital anomalies...
متن کاملRisk factors for latex sensitization in children with spina bifida.
BACKGROUND Children with spina bifida represent the major risk group for latex sensitization. PURPOSE To determine the prevalence of latex sensitization in these children and to identify risk factors. MATERIAL AND METHODS We studied 57 patients with spina bifida. The mean age was 5.6 years and the male/female ratio was 0.8/1. In all patients a questionnaire, skin prick test (SPT) with latex...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1995
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(95)91743-8